K H Nicolaides Selected Research

Down Syndrome (Down's Syndrome)

1/2021	Cell-free DNA testing of maternal blood in screening for trisomies in twin pregnancy: updated cohort study at 10-14 weeks and meta-analysis.
1/2020	Screening for trisomy at 11-13 weeks' gestation: use of pregnancy-associated plasma protein-A, placental growth factor or both.
1/2020	First-trimester screening for trisomies in pregnancies with vanishing twin.
1/2019	Routine first-trimester screening for fetal trisomies in twin pregnancy: cell-free DNA test contingent on results from combined test.
1/2019	Screening for trisomies by cfDNA testing of maternal blood in twin pregnancy: update of The Fetal Medicine Foundation results and meta-analysis.
9/2017	Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis.
6/2016	Screening for trisomies by cell-free DNA testing of maternal blood: consequences of a failed result.
6/2016	Prospective first-trimester screening for trisomies by cell-free DNA testing of maternal blood in twin pregnancy.
1/2016	Clinical implementation of routine screening for fetal trisomies in the UK NHS: cell-free DNA test contingent on results from first-trimester combined test.
1/2015	Screening for trisomies 21, 18 and 13 by cell-free DNA analysis of maternal blood at 10-11 weeks' gestation and the combined test at 11-13 weeks.

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K H Nicolaides Research Topics

Disease

85	Pre-Eclampsia (Preeclampsia) 01/2022 - 06/2000
53	Down Syndrome (Down's Syndrome) 01/2021 - 04/2000
31	Trisomy (Trisomies) 01/2021 - 05/2000
24	Aneuploidy (Aneuploid) 04/2018 - 12/2003
20	Birth Weight (Birth Weights) 01/2021 - 12/2001
16	Trisomy 18 Syndrome 01/2021 - 07/2000
14	Premature Birth (Birth, Premature) 01/2022 - 05/2002
13	Chromosome Aberrations (Chromosome Abnormalities) 01/2020 - 05/2000
12	Stillbirth 01/2022 - 03/2013
11	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2020 - 09/2000
9	Trisomy 13 Syndrome 01/2021 - 08/2000
9	Spontaneous Abortion (Miscarriage) 01/2021 - 10/2000
8	Fetal Distress 04/2019 - 07/2003
8	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 03/2016 - 10/2000
8	Pregnancy Complications 07/2015 - 10/2000
7	Perinatal Death 01/2020 - 09/2003
6	Fetal Death 01/2020 - 10/2006
6	Gestational Diabetes (Gestational Diabetes Mellitus) 08/2017 - 10/2000
6	Turner Syndrome (Turner's Syndrome) 10/2010 - 05/2000
4	Fetofetal Transfusion (Twin Transfusion Syndrome) 01/2020 - 09/2000
4	Fetal Weight 02/2016 - 08/2015
4	Diabetes Mellitus 07/2015 - 02/2004
4	Prolonged Pregnancy 10/2008 - 07/2003
3	Hypoxia (Hypoxemia) 02/2016 - 02/2001
3	Abnormal Karyotype 02/2008 - 10/2006
2	Hypertension (High Blood Pressure) 02/2022 - 12/2021
2	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 07/2019 - 04/2019
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2017 - 09/2016
2	Triploidy 06/2013 - 06/2000
2	Holoprosencephaly (Arhinencephaly) 02/2006 - 12/2005
2	Uterine Hemorrhage (Uterine Bleeding) 10/2004 - 01/2004
2	Anemia 05/2004 - 12/2001
2	Bone Resorption 08/2000 - 05/2000
1	Necrosis 12/2021
1	Ischemia 01/2021
1	Fetal Hypoxia 01/2021
1	Hydronephrosis 11/2020
1	Vasa Previa 01/2020
1	Cicatrix (Scar) 01/2019
1	Habitual Abortion (Recurrent Miscarriage) 05/2016
1	Pulmonary Hypertension 07/2013

Drug/Important Bio-Agent (IBA)

66	Pregnancy-Associated Plasma Protein-A (PAPP-A)IBA 01/2022 - 05/2000
43	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 11/2008
42	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2000
37	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/2020 - 08/2000
26	Cell-Free Nucleic AcidsIBA 01/2021 - 01/2013
24	Tyrosine (L-Tyrosine)FDA Link 01/2022 - 05/2015
19	Dihydrotachysterol (AT 10)IBA 06/2016 - 05/2000
12	DNA (Deoxyribonucleic Acid)IBA 09/2017 - 01/2013
9	antineoplaston A10 (A 10)IBA 01/2022 - 05/2008
7	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2020 - 09/2003
7	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2016 - 04/2000
5	Progesterone FDA LinkGeneric 01/2022 - 12/2006
5	activin AIBA 10/2008 - 04/2001
5	inhibin AIBA 10/2008 - 06/2000
5	Hemoglobins (Hemoglobin)IBA 05/2004 - 11/2001
4	Fetal Proteins (Fetoprotein)IBA 09/2015 - 01/2014
4	Proteins (Proteins, Gene)FDA Link 01/2006 - 02/2001
4	Fetal Hemoglobin (Hemoglobin F)IBA 05/2004 - 07/2000
3	EndoglinIBA 10/2014 - 12/2008
3	CollagenIBA 05/2002 - 05/2000
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2013 - 02/2001
2	CreatinineIBA 04/2009 - 06/2008
2	AlbuminsIBA 06/2008 - 10/2001
2	Fibronectins (Fibronectin)IBA 04/2006 - 10/2000
2	LeptinIBA 09/2005 - 05/2000
2	Tocolytic Agents (Tocolytics)IBA 10/2004 - 01/2004
2	SteroidsIBA 10/2004 - 01/2004
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2004 - 01/2004
2	Hyaluronic Acid (Hyaluronan)IBA 12/2003 - 05/2000
2	Placenta Growth FactorIBA 10/2001 - 09/2001
2	procollagen type I carboxy terminal peptide (PICP)IBA 08/2000 - 05/2000
2	Collagen Type I (Type I Collagen)IBA 08/2000 - 05/2000
2	A-factor (Streptomyces)IBA 08/2000 - 08/2000
2	Peptides (Polypeptides)IBA 08/2000 - 05/2000
1	Antihypertensive Agents (Antihypertensives)IBA 02/2022
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 12/2021
1	Endothelins (Endothelin)IBA 12/2021
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 12/2021
1	Potassium Chloride FDA LinkGeneric 11/2017
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 02/2017
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 05/2016
1	Heparin (Liquaemin)FDA LinkGeneric 05/2016
1	Natriuretic PeptidesIBA 02/2015
1	Atrial Natriuretic Factor (ANF)IBA 02/2015
1	Angiopoietin-2IBA 10/2014
1	Oxygen (Dioxygen)IBA 07/2013
1	Nicotinamide PhosphoribosyltransferaseIBA 04/2013
1	Vitamin D FDA LinkGeneric 02/2013

Therapy/Procedure

16	Cesarean Section (Caesarean Section) 01/2020 - 07/2003
6	Laser Therapy (Surgery, Laser) 01/2020 - 12/2001
5	Cardiopulmonary Resuscitation (CPR) 01/2021 - 04/2015
4	Sutures (Suture) 03/2006 - 12/2005
3	Induced Labor 04/2019 - 07/2003
3	Cervical Cerclage 11/2017 - 05/2002
2	Artificial Respiration (Mechanical Ventilation) 03/2017 - 07/2013
2	Prenatal Care (Care, Prenatal) 12/2006 - 08/2002
1	Surgical Amputation (Amputations) 11/2020
1	Enteral Nutrition (Feeding, Tube) 07/2013